简介
Sam Kariuki (DVM, MSc, PhD) obtained his DVM from the University of Nairobi (1989), MSc in Pharmacology and Toxicology, University of Nairobi (1991), and a PhD in Tropical Medicine from the Liverpool School of Tropical Medicine (LSTM) in 1997. He was awarded Doctor of Science (Honoris causa) by the LSTM in December 2022. Sam Kariuki is currently Director, Drugs for Neglected Diseases Initiative (DNDi) Eastern Africa. Previously, he was Acting Director General at the Kenya Medical Research Institute (KEMRI) (2021-2023) and Director of Research and Development (2018-2022). He is Fellow, African Academy of Sciences and Honorary Faculty, Wellcome Sanger Institute, visiting Professor of Tropical Microbiology, Nuffield Department of Medicine, University of Oxford, and the Ohio State University One-Health Initiative. He is also a member of the American Society for Microbiology and Section Editor, Journal of Medical Microbiology.
Over the last 25 years his team has researched and published on the epidemiology and genomics of Antimicrobial Resistance (AMR) and genomic surveillance of key enteric pathogens endemic in Kenya and the region. Their findings have been instrumental in informing policy change in first line-treatment, prevention and control strategies for key enteric pathogens including cholera, typhoid fever, and invasive non-typhoidal Salmonella disease. He has published over 200 papers in peer-reviewed journals and written 4 chapters in textbooks of Microbiology and Infectious Diseases, majoring in Genomics and Epidemiology. He is a member of the National Antimicrobial Stewardship Interagency Committee (NASIC) advising Ministry of Health on One Health approach in implementation of the National Action Plan to combat AMR, and a member of the WHO Strategic and Technical Advisory Group for Antimicrobial Resistance (STAG-AMR).
Some key publications:
1. Kering K, Wang Y, Mbae C, Mugo M, Ongadi B, Odityo G, Muturi P, Yakubu H, Liu P, Durry S, Deshpande A, Gebreyes W, Moe C, Kariuki S. Pathways of exposure to Vibrio cholerae in an urban informal settlement in Nairobi, Kenya. PLOS Glob Public Health. 2024 Aug 20;4(8):e0002880. doi: 10.1371/journal.pgph.0002880.
2. Kariuki S, Onsare RS. High burden of typhoid disease in sub-Saharan Africa calls for urgent roll-out of typhoid conjugate vaccines. Lancet Glob Health. 2024 Apr;12(4):e537-e538.
3. Kasiano P, Kavai S, Kiiru S, Nyerere A, Kariuki S. Typhoidal salmonella disease in Mukuru informal settlement, Nairobi Kenya; carriage, diversity, and antimicrobial resistant genes. PLoS One. 2024 Feb 23;19(2):e0298635.
4. Kiiru S, Maina J, Mwaniki JN, Songoro E, Kariuki S. Enteric bacterial agents
associated with diarrhea and their antimicrobial sensitivity profiles in
children under 5 years from mukuru informal settlement, Nairobi, Kenya. BMC
Infect Dis. 2024 Feb 22;24(1):237.
5. Mendelson M, Laxminarayan R, Limmathurotsakul D, Kariuki S, Gyansa-Lutterodt M, Charani E, Singh S, Walia K, Gales AC, Mpundu M. Antimicrobial resistance and the great divide: inequity in priorities and agendas between the Global North and the Global South threatens global mitigation of antimicrobial resistance. Lancet Glob Health. 2024 Mar;12(3):e516-e521.
6. Browne HP, Iqbal NT, Osman M, Tigoi C, Lawley TD, Gordon JI, Ahmed T, Kariuki S. Boosting microbiome science worldwide could save millions of children's lives. Nature. 2024 Jan;625(7994):237-240.
7. Mendelson M, Laxminarayan R, Limmathurotsakul D, Kariuki S, Gyansa-Lutterodt M, Charani E, Singh S, Walia K, Gales AC, Mpundu M. Antimicrobial resistance and the great divide: inequity in priorities and agendas between the Global North and the Global South threatens global mitigation of antimicrobial resistance. Lancet Glob Health. 2024 Jan 23:S2214-109X(23)00554-5.
8. Meiring JE, Khanam F, Basnyat B, Charles RC, Crump JA, Debellut F, Holt KE, Kariuki S, Mugisha E, Neuzil KM, Parry CM, Pitzer VE, Pollard AJ, Qadri F, Gordon MA. Typhoid fever. Nat Rev Dis Primers. 2023 Dec 14;9(1):71.
9. Crump JA, Nyirenda, TS, Kalonji LM, Phoba M-F, Tack B, Platts-Mills JA, Gordon MA, Kariuki S. Nontyphoidal Salmonella invasive disease: challenges and solutions. Open Forum Infect Dis 2023; 10 (suppl 1): S32-37.
10. Kariuki K, Diakhate MM, Musembi S, Tornberg-Belanger SN, Rwigi D, Mutuma T, Mutuku E, Tickell KD, Soge OO, Singa BO, Walson JL, Pavlinac PB, Kariuki S. Plasmid-mediated quinolone resistance genes detected in Ciprofloxacin non-susceptible Escherichia coli and Klebsiella isolated from children under five years at hospital discharge, Kenya. BMC Microbiol. 2023 May 13;23(1):129.
11. Kariuki S, Kering K, Wairimu C, Onsare R, Mbae C. Antimicrobial Resistance Rates and Surveillance in Sub-Saharan Africa: Where Are We Now? Infect Drug Resist. 2022
Jul 7;15:3589-3609.
Blogs:
Typhoid and TCV: https://www.coalitionagainsttyphoid.org/genomic-analysis-takes-a-closer-look-at-drug-resistant-typhoid-in-east-africa/
