Since 01/2007
Director, Institute of Structural Biology, Helmholtz Zentrum München, Germany;
Professor (W3) Biomolecular NMR-Spectroscopy, Dept Chemie, TU München;
Director, Bavarian NMR Center (BNMRZ)
Integrated structural biology of protein complexes; structural biology of RNA-based gene regulation, peroxisomal biogenesis and signaling, disease mechanisms; structure-based drug design
08/1997-12/2006
Group Leader, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
Structural biology in RNA-based regulation of gene expression: pre-mRNA splicing, RNAi and signal transduction; NMR methods for large protein complexes
02/1995-08/1997
Postdoctoral Associate, Abbott Laboratories, Abbott Park, USA.
Advisor: Dr. Stephen W. Fesik
Structural biology of protein complexes in signaling and apoptosis: Shc-PTB/Trk-peptide complex, Bcl-xL; Bcl-xL/Bak complex
08/1991-01/1995
Doctoral research, University of Frankfurt, Germany
Advisor: Prof. Dr. Christian Griesinger „Development and implementation of novel multidimensional heteronuclear NMR methods with improved sensitivity for biomacromolecules“
研究方向
RNA Research and SplicingRNA and protein synthesis mechanismsRNA modifications and cancerProtein Structure and DynamicsEnzyme Structure and Function
