Ludo Van Den Bosch

My research focuses on the cause, mechanism and treatment options for neurodegenerative diseases. In particular, we study amyotrophic lateral sclerosis (ALS, Lou Gehrig’s disease) and its relation to frontotemporal dementia, as well as Charcot-Marie-Tooth disease (an axonal peripheral neuropathy). We perform genetic studies, study in vitro models and fruit fly, fish, mouse and rat models, and have an intensive clinical research program. We aim to translate results from genetic and animal studies to biomarker aspects and treatment strategies. We have contributed significantly to the development of in vitro motor neuron models (including iPSC-derived motor neurons). The fish model for ALS that we developed, has found its way to many other groups, and allowed genetic screens for the identification of modifiers. These research activities have resulted in many papers in top journals.