简介
Name: Univ. Prof. Dr. Gergely Szakács, M.D., Ph.D.
Date and Place of Birth: March 20, 1970; Hungary
Citizenship: Hungarian
Email: gergely.szakacs@meduniwien.ac.at
Address: Medical University of Vienna, Instititute of Cancer Research, Borschkegasse 8a, 1090 Vienna, Austria
Marital Status: Married, 2 children (2005, 2007)
Education:
2001 Ph.D. in Biochemistry, Doctoral School, Semmelweis University of Medicine, Budapest, Hungary.
1995 M.D., Semmelweis University of Medicine, Budapest, Hungary.
Research and professional experience:
2015 Full Professor, Institute of Cancer Research, Medical University of Vienna
2008 Group Leader, Laboratory of Membrane Proteins at the Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences
2006 Senior Research Fellow at the Institute of Enzymology, Hungarian Academy of Sciences
2001-2005 Postdoctoral Fellow at the Laboratory of Cell Biology (LCB), National Cancer Institute, National Institutes of Health (Dr. Michael Gottesman)
1995-2001 Graduate research training at the Membrane Research Group of the Hungarian Academy of Sciences (National Institute of Haematology and Immunology, Budapest), under the mentorship of Dr. Balázs Sarkadi.
1995 Internship at UMDNJ, New Jersey’s University of Health Sciences
1993-1994 Research Fellow at the Institute of Enzymology, Hungarian Academy of Sciences, group of Dr. András Váradi.
Honors and Awards:
2012 ERC Starting Grant
2008 EMBO YIP SDIG Fellow
2007 Marie Curie IE Fellow
2006 Leukemia &Lymphoma Society Fellow
2006 Outstanding Postdoc (Center for Cancer Research, NCI, NIH)
2006 Federal Technology Transfer Award, National Cancer Institute
2005 Bolyai Fellowship (Hungarian Academy of Sciences)
2005 Federal Technology Transfer Award, National Cancer Institute
1999 Soros Predoctoral Fellow
1996 Tempus-Phare Scholar, Kremlin-Bicetre Hospital, University XI. Paris
1995 1st Prize, Student Research Conference, Semmelweis University of Medicine
1994 Clinical fellowship at Whytham Hall (Hospital for the Homeless), London
Societies:
Hungarian Biochemical Society (member of FEBS), since 1996
Peer Review Activity:
Editor, Plos One
Peer reviews for Biochemistry, Journal of Biological Chemistry, Cancer Research, Future Oncology, Bioscience Reports, Cell Biochemistry and Biophysics, Expert Opinion On Drug Metabolism & Toxicology
Research Interests:
Drug resistance in cancer, ABC transporters, collateral sensitivity
6 most relevant publications (from ~120 papers; sum of the times cited: ~12500; h-index: 43)
1. Szakács G, Hall MD, Gottesman MM, Boumendjel A, Kachadourian R, Day BJ, Baubichon-Cortay H, Di Pietro A.(2014): Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance. Chem Rev. 2014 Jun 11;114(11):5753-74.
2. Kiss K, Kucsma N, Brozik A, Tusnady GE, Bergam P, van Niel G, Szakacs G.(2015): Role of the N-terminal transmembrane domain in the endo-lysosomal targeting and function of the human ABCB6 protein. Biochem J. 2015 Apr 1;467(1):127-39.
3. Szakács G, Váradi A, Ozvegy-Laczka C and Sarkadi B (2008): The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox).Drug Discov Today 13, 379-393.
4. Türk D, Hall MD, Chu BF, Ludwig JA, Fales HM, Gottesman MM and Szakács G (2009): Identification of Compounds Selectively Killing Multidrug-Resistant Cancer Cells. Cancer Res 69, 8293-301.
5. Szakács G, Paterson JK, Ludwig JA, Booth-Genthe C and Gottesman MM (2006): Targeting multidrug resistance in cancer. Nat Rev Drug Discov 5, 219-34.
6. Szakács G, Annereau JP, Lababidi S, Shankavaram U, Arciello A, Bussey KJ, Reinhold W, Guo Y, Kruh GD, Reimers M, Weinstein JN and Gottesman MM (2004): Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells. Cancer Cell 6, 129-37.
