Over the last decade, I have gained significant expertise in RNA therapeutics for the treatment of cancer. Using RNA nanotechnology, I have constructed several RNA nanoparticles with defined structure and stoichiometry to carry multiple functionalities for regulating cellular functions (Molecular Therapy, 2019; ACS Nano, 2019; ACS Nano, 2015; Nature Nanotechnology, 2011; Nano Today, 2011; Nano Letters, 2004). In addition, I have plenty of experience in single molecule biophysical techniques, such as FRET for understanding the structure-function relationship of RNA motifs (ACS Nano, 2010; EMBO Journal, 2007; RNA, 2007). My long-term objective is to focus on the development and translation of RNA nanotechnology-based products into clinical trials. I have extensive experience in cancer biology, animal model development and RNA therapeutics, which will ensure the success of this proposal.
研究方向
RNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesRNA and protein synthesis mechanismsBacteriophages and microbial interactionsMicroRNA in disease regulation
