Anne‐Claude Gingras

Anne-Claude Gingras is the Vice President of Research at Sinai Health, Toronto, ON, and Director of the Lunenfeld-Tanenbaim Research Institute. She holds the Canada Research Chair in Functional Proteomics and the Louis Siminovitch Sinai 100 Chair and is a Senior Investigator at the Lunenfeld-Tanenbaum Research Institute. A Full Professor in the department of Molecular Genetics at the University of Toronto, she also serves as co-director of the Network Biology Collaborative Centre. Her lab focuses on the study of signalling pathways using systematic approaches and the development of quantitative proteomics technologies. She has developed experimental and bioinformatics approaches to confidently identify, quantify, and visualize interaction and proximity partners for proteins of interest. She continues to be a strong advocate for data transparency and data sharing, and for the development of user-friendly bioinformatics tools. Using the tools that she developed, her group has identified new protein complexes and signaling components that provide a better understanding of perturbations associated with cancer and rare diseases. She has also implemented innovative strategies for the interpretation proximity-dependent biotinylation (BioID) data that can reveal the organization of membraneless organelles inside living cells, and more recently, of all organelles in the cell (humancellmap.org). She took on a leadership role during the pandemic by developing and deploying automated antibody monitoring approaches to analyze the response to SARS-CoV-2 infection or vaccination. She also implemented neutralization assays to profile the response to circulating variants of concern, with a focus on vulnerable populations. Dr. Gingras has published >350 research articles and review articles that have already been cited >60,000 times. She is a Fellow of the Royal Society of Canada, an elected member of the European Molecular Biology Organization (EMBO), and was recently awarded the CSMB Jeanne Manery Fisher Memorial Lecture (2019), the HUPO Discovery Award (2019), and the CNPN Tony Pawson Award (2020).